Which command is specifically charged with missile defense and combating weapons of mass destruction?

The correct answer is US Strategic Command (USSTRATCOM) because it is specifically designated with the mission of missile defense and the overarching responsibility for combating weapons of mass destruction. USSTRATCOM plays a critical role in the defense posture of the United States, overseeing strategic deterrence and ensuring that the nation can defend against potential threats involving nuclear, biological, and chemical weapons. This command integrates various military capabilities and collaborates with other government units and international partners to provide a comprehensive approach to national security in these areas.

The other commands listed have different focuses and missions. While Air Combat Command (ACC) is primarily responsible for the training and equipping of combat-ready air forces, US Special Operations Command (USSOCOM) focuses on organizing, training, and equipping special operations forces. US Southern Command (USSOUTHCOM) concentrates on planning and coordinating military operations in Central and South America and the Caribbean. These distinct missions separate their roles from the specific objectives of missile defense and combating weapons of mass destruction assigned to USSTRATCOM.